Why do some people eat high cholesterol foods cause cardiovascular and cerebrovascular diseases, and some people eat it is very healthy? Find the body's mechanism to regulate cholesterol levels, which is the School of Life Sciences of Wuhan University Professor Song Baoliang has been the subject of research. Recently, the "Science" magazine published the latest results of Song Baoliang's research group in the form of a research paper. They found a new gene from the human body that can regulate the absorption of cholesterol in the human body. This finding provides a cure for hyperlipidemia. New drug development targets. Studies have shown that cholesterol levels are mainly regulated by two aspects, dietary lifestyle on the one hand, and genetic factors on the other. From the perspective of human genetics to explore the regulation mechanism of cholesterol, which is the subject of Song Baoliang team research. The content of LDL-C between different races and the incidence of coronary heart disease are very different. In order to reveal new cholesterol-regulating genes, Song Baoliang's research group cooperated with the team of Xinjiang Medical University's Ma Yixin to discover a familial low level through epidemiological surveys. The LDL-C Kazakh family, through genome-wide exon sequencing and gene association analysis, found that the rare frameshift mutation (K306fs) of the LIMA1 gene was significantly associated with low LDL-C. In order to understand the causality and mechanism of action between genetic variation and cholesterol, the team went on to conduct more in-depth research. Analysis of variant carriers revealed a decrease in their cholesterol absorption. This finding was confirmed and reproduced in knockout mice. Through the molecular level research, it further reveals its function and mechanism of mediated cholesterol absorption in the small intestine, which also provides a new target for the intervention of human blood lipids.
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