Release date: 2016-09-18 The drug is the main treatment for neuralgia after spinal cord injury, but it continues to significantly relieve pain and has potential side effects. At present, there are related guidelines for the treatment of neuropathic pain, but they are based on clinical evidence, rather than the mechanism of action, and the therapeutic effect is not satisfactory. Therefore, these guidelines need to be revised to distinguish subgroups of neuropathic pain to make drug treatment more effective. The first recommended drugs for the treatment of neuralgia after spinal cord injury include anticonvulsants and psychotropic drugs. Pregabalin can attenuate voltage-gated calcium channel function, reduce neurotransmitter release, reduce spinal cord sensitivity, and relieve pain. Carbamazepine is an anti-caries agent that acts on voltage-gated sodium channels to reduce the high excitability of damaged peripheral nerves. Oxcarbazepine is commonly used to reduce the incidence of rash due to the frequent adverse reactions of rash. In order to clarify the effects of the above two drugs on different neuralgia and to find the best treatment for neuralgia, Kyunghoon Min from the Department of Rehabilitation Medicine and Psychiatry of CHA University in Korea designed a prospective randomized crossover design study and will study The results were published in the May 2016 issue of American journal of physical medicine & rehabilitation. The study included 55 patients with spinal cord injury, aged ≥ 20 years, with neuropathic symptoms and a LANSS score (Leeds assessment of neuropathic symptoms and signs) ≥ 12 points, VAS ≥ 3 points. Patients were divided into induction pain group (including tactile stimulation induced pain, thermal hyperalgesia and stress hyperalgesia) and non-induced pain group (electric shock pain, burning pain, tingling and numbness) according to the symptoms and signs of neuralgia. According to the pain site, the pain is divided into plane pain and plane pain. Plano pain refers to the pain that occurs between the two segments above and below the plane of the spinal cord injury. It can be further divided into root pain (the pain mechanism may be radiculopathy) and central pain (the pain mechanism may be the supraspinal structural damage). ). Planar neuralgia refers to pain that is at least three segments below the plane of injury and may be related to the spinal thalamic cortical pathway. Each type of pain was scored using VAS before taking the drug. A total of 28 patients taking pregabalin at the initial dose of 150 mg / d, taken in 2 divided doses, according to the patient's response and tolerance gradually increased to 300 mg / d within 1 to 2 weeks, continue to take The VAS assessment was performed again for more than 1 week. Twenty-seven patients who received oxcarbazepine were given a starting dose of 150 mgbid, gradually added to 300 mgbid, and continued to take VAS for more than 1 week. Then the two groups of patients stopped taking the first drug and started taking the second drug. The above medication procedure was repeated, and the VAS assessment was performed again after 1 to 2 weeks of continuous administration. Since plane pain and subplanar pain were included as independent pain studies, 55 patients with spinal cord injury eventually included 66 data for analysis. The study found that oxcarbazepine is more effective for non-induced pain, including electric shock, burning pain and tingling. In addition to burning pain, pregabalin did not differ in the effects of other induced and non-induced pain. Among the patients with induced pain, pregabalin is more effective than oxcarbazepine in electric shock, touch-induced pain and thermal hyperalgesia. In patients with non-induced pain, oxcarbazepine was more effective in improving pain than pregabalin, but the difference was not statistically significant. Studies have shown that different types of neuralgia can be treated with different medications. Symptomatic treatment can relieve pain more effectively. Source: Lilac Garden Dishwash Liquid,Dish Washing Soap,Dish Washer Detergent,Kitchen Dishwashing Liquid Detergent Wuxi Keni Daily Cosmetics Co.,Ltd , https://www.wxkenidaily.com