New male contraceptives: reduce sperm without inhibiting sexual desire March 29, 2019 Source: Sina Technology Sina Technology News Beijing time on March 28th news, according to foreign media reports, the latest male contraceptive method is considered safe by researchers, they have now tested this new drug in some male groups. This is the second promising male oral contraceptive pill, after which a male birth control gel has been put into clinical trials. The new male oral contraceptive is an important milestone in the research field, but this does not mean that doctors will prescribe a new contraceptive treatment tomorrow. In fact, it takes about 10 years for male contraceptives to be available. The drug is currently in the development and approval phase, and researchers at the Los Angeles Institute of Medicine and the University of Washington say the drug can safely reduce the hormones needed for sperm without killing male sexual desire. At present, human intelligence provides only three measures to prevent pregnancy. There are currently two extreme measures: vasectomy is a surgical procedure that prevents sperm from entering semen, and is a very long solution; male condoms And "external ejaculation" are used when sexual activity occurs. In contrast, women have many contraceptive measures, but none of them have no side effects, and almost all measures interfere with the level of hormones in women, thus playing a contraceptive effect. Long-term female contraceptives must be inserted into the body, a process that is very painful for women, and “painless contraceptives†can lead to weight gain and nausea. Therefore, male birth control is a long-awaited innovation, whether it is men who control birth control or women who are unwilling to bear the pain of contraception, they are very much looking forward to male birth control methods. In recent years, male birth control measures have finally made some new progress. The previous gel material applied to the back and shoulders of men has appeared, and its appearance will make many women feel dissatisfied because the condoms they often use tend to have more body. Invasive. This male birth control gel is in clinical trial and is expected to end in 2022. Research reports indicate that the latest oral male contraceptive has passed an important safety test for the first time. This new oral drug, called 11-beta-MNTDC, is an improved synthetic testosterone. It acts on androgens, also on progesterone, a hormone that promotes pregnancy in the female ovary, and also causes testosterone in the male endocrine system. The researchers believe that 11-beta-MNTDC can reduce the number of sperm in the testis while maintaining normal testosterone levels in other parts of the body. In a test of 40 adult males (10 of whom took a placebo), the oral medication was able to reduce hormone secretion to a male hormone deficiency state. Male testers take a dose of 200 or 400 mg per day for 28 days. At the end of the study, no one stopped taking the drug, although some people showed minor side effects such as fatigue, headache or hemorrhoids. Five male testers said they had lower libido, but their sex life was the same as usual. Although the hormone levels in the testers have dropped significantly, the researchers say that the sperm count itself takes 60-90 days to decline, but the drug actually blocks the two hormones involved in the sperm manufacturing process. Male testes produce 1,500 sperm per second, which is one of the reasons why the latest male contraceptives have taken effect for so long, and is part of the reason why male birth control techniques fail to develop earlier. Of course, this is not the only reason, because trial drugs can cause liver damage, and the motivation of pharmaceutical companies to make male birth control drugs is unknown. Scientists at the Los Angeles Institute of Medicine and the University of Washington are not yet sure if the drug is effective, but they know it is safe, and its efficacy to date is still worth looking forward to. The researchers also conducted a safety test on another male contraceptive made by the same company. Dr. Stephanie Page, a professor of medicine at the University of Washington School of Medicine, said that our goal is to find the least effective and most effective compound. . No matter which drug can be verified, it will take a while to get on the market. The next phase of the drug approval process takes 2 years and 3 years, respectively, and the US Food and Drug Administration assessment may take 2 years. But late, it’s better than not doing it. Christina Wang, deputy director of the Los Angeles Institute of Biomedical Research, said: “Safe, reversible male hormonal contraception should be achieved in about 10 years. ("Ye Liancheng) Hydrocolloid Applicator,Hydrocolloid Dressing,Hydrocolloid Band Aid,Hydrocolloid Gel Patches Henan Maidingkang Medical Technology Co.,Ltd , https://www.mdkmedical.com