Oral **** potential danger

Oral ketoconazole tablets are potentially dangerous Recently, the U.S. Food and Drug Administration (FDA) announced that ketoconazole tablets should not be used as first-line treatment for fungal infections because the treatment is associated with adrenal insufficiency, potentially lethal hepatotoxicity, and drug-drug interactions.

According to a safety alert issued by MedWatch, oral ketoconazole tablets under the trade name “Nizoral” are no longer suitable for the treatment of Candida and dermatophyte infections. In addition, oral ketoconazole tablets should not be used to treat fungal infections of the skin and nails. It is only suitable for the treatment of blastomycosis, coccidioidomycosis, histoplasmosis, and other diseases that are ineffective or incompatible with other therapies. Patients with chromomycosis and paracocciomycosis. The product's instructions have been modified to indicate risk warnings.

Because oral ketoconazole is associated with hepatotoxicity that can lead to liver transplantation or death, it is currently contraindicated in patients with acute or chronic liver disease. In addition, ketoconazole tablets are potential inhibitors that, in combination with other drugs, increase the plasma concentration of the concomitant drug and the risk of QT prolongation syndrome and other serious reactions. Drugs that are forbidden to use in combination include Dufilid, Quinidine, Pimozide, and Cisapride.

Daidzein

[ Name ] daidzein,2. Alias; Daidzein; Daidzin yuan

[ English name ]Daidzein
Molecular formula: C15H10O4
Molecular weight: 254.24
[CAS Number] 486-66-8
[Detection Method] HPLC≥98%
[ Specification ]10mg 20mg 100mg 500mg 1G (according to customer demand packaging)
[ Properties ] This product is light yellow crystal
[ Function and use ] This product is used for content determination.
[Extraction source]
It is the yellow seed coat of Glycine Max (L) merr of soybean, a leguminous plant.
[ Pharmacological properties ]
For the treatment of menopausal syndrome, prostate cancer, breast cancer, heart disease, cardiovascular disease, osteoporosis.
[usage]
Chromatographic conditions: acetonitrile :0.4% phosphoric acid water =40%:60% detection wavelength :260nm (for reference only)
[Storage method]
Store at 2-8°C, away from light.

[Precautions] This product should be stored in low temperature, exposure to the air for a long time, the content will be reduced.

Daidzein is also known as daidzein, daidzein, daidzein. White to off-white crystalline powder (crystallized from 50% ethanol) sublimated in high vacuum. Soluble in ethanol and ether. Melting point 315 ~ 323℃(decomposition), uv absorption peak 250nm. Flake crystallization (from acetone), melting point 315 ~ 316℃. It is found in the roots of the leguminous plant Pueraria lobata(Willd) Ohwi, the whole leguminous plant Red clover (Trifolium pratense L.), and the whole purple clover (Medicago sativa L.). It has estrogen-like effect and synthetic daidzein has obvious anti-hypoxia effect.

Daidzein,menopausal syndrome,prostate cancer

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