Removal of senescent cells slows cognitive decline in mice October 11, 2018 Source: Chinese Journal of Science Recently, a paper published online by Nature reported the causal relationship between mouse aging cells and neurodegeneration. The findings open up a potentially new way to treat neurodegenerative diseases. Past studies have shown that with age, aging cells (dysfunctional cells that lose their ability to divide) accumulate in the body and actively promote tissue degeneration. Removing these cells can resist many of the effects of aging. Senescent cells are also detected in the context of brain aging and neurodegenerative diseases, but their role in this is unclear. Darren Baker of the Mayo Clinic in the United States and colleagues used transgenic mice to mimic neurodegenerative diseases and reported the accumulation of senescent cells in the hippocampus and other brain regions. Removal of these cells by genetic modification throughout the life of the mouse reduces neuronal tau phosphorylation (and subsequent accumulation of neurofibrillary tangles) and prevents neuronal degeneration in the cortex and hippocampus (both brains) The district participates in the cognitive process). The results showed that modified mice exhibited reduced memory loss compared to unmodified mice, which means that senescent cells promote neurodegeneration and loss of cognitive function. The researchers say the findings suggest that continuous removal of senescent cells may have a major impact on disease progression before the onset of neurodegenerative disease in model mice. However, further research is needed to determine whether these findings are applicable to humans and whether clinical transformation can be achieved. (Lu Yi) Related paper information: DOI: 10.1038/s41586-018-0543-y Chinese Journal of Science and Technology (2018-10-11 2nd Edition International) herpes zoster vaccine,Hepatitis B Vaccine For Adults,Tetanus Booster,Td Vaccine FOSHAN PHARMA CO., LTD. , https://www.full-pharma.com