Study to determine new lung cancer predisposing factors

Using the OncoArray genotyping platform developed by several cancer consortia, a number of recent polymer-genomic association studies have identified new susceptibility loci for lung cancer, which is the leading cause of cancer mortality worldwide. Although smoking is a major risk factor, past studies have shown that the heritability of lung cancer is estimated at 18%. Previous genomic association studies have identified several lung cancer susceptibility loci, but most of their hereditary remains unexplained. This study performed additional genotyping of lung cancer cases and controls.

The study was led by Dr. Christopher Amos, Interim Director and Deputy Director of Population Science at Norris Cotton Cancer Center, Dr. James McKay of the International Agency for Research on Cancer; Dr. Rayjean Hung, Lenenfeld-Tanenbaum Institute and University of Toronto, and many lung cancer surveys worldwide. Members participate in the research. A total of 14,803 cases and 12,262 European pedigree controls and available data, a total of 29,266 cases and 56,450 controls. The researchers identified 18 susceptible loci for genome-wide significance, including 10 new loci. The new locus highlights significant changes in the risk pattern between lung cancer subtypes of adenocarcinoma and squamous cell lung cancer, four loci associated with lung cancer and six loci associated with lung adenocarcinoma. Variants of several genes associated with telomere function were found to play an important role in the contribution to adenocarcinoma risk, but had no significant effect on the risk of squamous cell carcinoma.

Their findings, "The large-scale association analysis to determine the heterogeneity of new lung cancer susceptibility loci and histological subtype genetic susceptibility," will be published in the forthcoming journal Nature Genetics.

“What is particularly exciting is the importance of the research and the new findings of genes that have not been reported to affect lung cancer,” Amos said. “This study will certainly lead to new ideas about the mechanisms that affect lung cancer risk, especially if we have determined Several novel variants affecting telomere function affect the risk of lung adenocarcinoma. In addition, we found that the variation of nicotinic receptor subunits and smoking behavior that affect lung cancer risk seem to play a major role in the cerebellum, which is rarely involved. Affecting addictive behavior. Further research will provide a better understanding of the role of target genes in influencing lung cancer risk, smoking behavior and the effects of smoking on brain biology.