Intermediate – Intermediate: A material produced during a drug substance processing step that must undergo further molecular modification or refinement to become a drug substance. Intermediates may or may not be isolated. Intermediates are the key products of the previous process of making APIs, which are different in structure from APIs.
Ceftriaxone sodium powder is called preparation, sterile ceftriaxone sodium is called API, and 7-ACA is called intermediate.
Our company specializes in providing key intermediates for various APIs
Intermediate is a very important type of fine chemical products. Its essence is a type of "semi-finished product", which is an intermediate product in the production of certain products. For example, if a product is to be produced, it can be produced from intermediates, saving costs and reducing It is widely used in the synthesis of medicines, pesticides, coatings, dyes and spices. In the field of medicine, intermediates are an important link in the industrial chain of the pharmaceutical industry. They are used for some chemical raw materials or chemical products in the process of drug synthesis. In a word, they are used to produce APIs.
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for example:
Amoxicillin capsules are called preparations, amoxicillin is called API, and 6-APA is called intermediate.
The difference between polar spectrometry and atomic absorption spectrometry
With the continuous improvement of people's living standards, people pay more and more attention to their own health and pay attention to the role of trace elements in the body. 81 elements have been found in the human body, including 11 kinds of macro elements, accounting for nearly 99.95% of the total mass of the human body. The remaining 70 elements are trace elements, accounting for only 0.05% of the total mass of the human body, accounting for nearly 0.01% of the total mass of the human body. The following are trace amounts. In the clinical test, calcium (nearly 1.5%), magnesium (nearly 0.05%), and phosphorus (1%) are also classified as trace elements. These trace elements play an important role in the body, so the detection has become one of the new projects carried out by the hospital. Now, the two methods of micro-element analyzer detection are compared.
Method 1: The principle of atomic absorption detection: When the radiation of a certain characteristic wavelength emitted by the light source passes through the atomic vapor, it is selectively absorbed by the outside of the atom, so that the intensity of the incident amplitude transmitted through the atomic vapor is weakened. When the experimental conditions are constant, the atomic concentration in the vapor term is proportional to the content of the element in the sample, so the degree of attenuation of the incident radiation is proportional to the content of the element in the sample.
Method 2: Polarographic analysis method: In the electrolytic cell containing the solution of the substance to be tested, a saturated calomel electrode and a mercury-dropping motor are inserted. At the end of the life of the mercury droplet, the substance to be tested is reduced on the mercury droplet to produce electrolysis. The current is controlled by the rate at which ions diffuse from the body of the solution to the surface of the electrode, which is related to the ion concentration, from which it can be determined.
In practical applications, the trace element analyzer for polarographic analysis is more widely used than the second one because the second detector is expensive and the former results are very different from the latter. Cornell trace element detector is based on national standard substance calibration, the test results are accurate and reliable, welcome to consult.