The first quantification of the effects of smoking on DNA: every DNA mutation can trigger genetic damage November 09, 2016 Source: Bio Valley According to the New Scientist website, a study published in the journal Science said that on average, every 50 lungs produced a DNA mutation per lung cell. Smokers who smoked 20 cigarettes a day for one year, each lung cell, throat cell, pharyngeal cell, bladder cell and kidney cell will produce 150, 97, 39, 18 and 6 DNA respectively. mutation. This is the first time researchers have quantified the effects of molecular damage on DNA. Previously, epidemiological studies have indicated that smoking is associated with at least 17 cancers. Ludmir Alexandrov and colleagues at Los Alamos National Laboratory in New Mexico, USA, compared the tumor DNA of 2,500 smokers and 1,000 non-smokers, which allowed them to identify which mutations were associated with smoking. . In theory, each DNA mutation may trigger a cascade of genetic damage that causes cell cancer. However, it is unclear how likely a DNA mutation associated with smoking will turn into cancer, or which types of mutations may become more malignant. This is what Alexandra has studied. Alexandrov said that although some smokers have accumulated thousands of mutations in their bodies, they have never developed cancer, but this is entirely due to luck. “Smoking is like playing a Russian roulette game: the more you play, the more likely a mutation affects a good gene and the risk of getting cancer. However, there are always people who smoke a lot but the mutation does not affect the good genes. He pointed out that every cigarette can cause genetic mutations, and hope that their discovery will prevent people from smoking too much smoke and breaking the myth that social smoking is harmless. It is worth mentioning that smoking damage to DNA is permanent and will not be reversed because of smoking cessation. However, smoking cessation can prevent the risk of more mutations. Simon Chapman, an emeritus professor at the University of Sydney in Australia, said there is evidence that smoking cessation can significantly reduce the risk of premature death. A British study showed that smokers lived 10 years shorter than their average life expectancy. However, smoking cessation at age 30 almost eliminates the risk of premature death, and quit smoking at 50 years halve this risk. “Many smokers believe that quitting smoking is not beneficial because the damage has already occurred. But if you quit smoking in the middle age, you can avoid almost all the risk of death associated with smoking.†Alloy Steel Co2 Fire Extinguisher Alloy Steel Co2 Fire Extinguisher,Alloy Steel Fire Extinguisher,Co2 Alloy Steel Fire Extinguisher,Carbon Dioxide Fire Extinguisher JIANGSU NEW FIRE FIGHTING TECHNOLOGY CO.,LTD , https://www.newayfire.com