If an egg wants to grow up healthily, it needs DNA to give the "code of life" to the due "postman", mRNA, which is then correctly translated into a protein that performs its function. The reporter learned from Nanjing Medical University on November 14 that the team of Professor Su Youqiang discovered that the new gene Marf1 and its domain NYN can control mRNA transcription and degradation. The results have been published in the latest issue of the Academy of Sciences. The quality of the egg directly determines the reproductive status of women. If the "postman" of mRNA is unstable and sent to the letter, it will lead to some protein expression disorder, and the egg will not grow healthily. This is the disease that causes female infertility, birth defects and other diseases. One of the important reasons. From the oocyte maturation to the formation of early embryos after fertilization, the mRNA "poster" from the mother is gradually "dismissed" - that is, all of them are degraded, and finally the "belonging" mRNA is finally transcribed. "postman". In 2012, Professor Su Youqiang discovered and named the new gene Marf1. Marf1 is a very important gene for female reproduction. The deletion of Marf1 protein causes some "postman" in mice - mRNA transcription level is up-regulated, higher than Normal levels cause the oocyte to become immature and unable to develop into an embryo, leading to infertility. Eggs that have experienced Marf1 mutations can grow up, but they can't mature, just like a tomato. Although they can grow up, they are always blue. Recently, the team of Su Youqiang and the team of Professor Ma Jinxi of Fudan University found that a very important domain of NYN in Marf1 protein can degrade mRNA. If NYN is lost, it will produce almost the same results as the deletion of Marf1 protein, indicating that Marf1 protein functions to degrade mRNA through the NYN domain. Researchers said: "If redundant mRNA is not degraded in time, it will have a negative effect on the cells. Once the Marf1 protein is gone, or the NYN domain is destroyed, it will not be able to perform the degradation function, resulting in redundancy. The remaining mRNA still exists, which has an adverse effect." (Reporter Zhang Wei) Anti Bird Netting,Anti Bird Net For Balcony,Anti Pigeon Net,Anti Bird Mesh Changzhou Satidi Import and Export Co., Ltd. , https://www.guanjiejts.com