Recently, it has been hailed as the fourth largest field of anti-tumor treatment in addition to surgery, radiotherapy and chemotherapy. Tumor immunotherapy is widely heated. From the first generation of LAK, NK, CIK treatment lacking targeting; the second generation DC-CIK treatment that confers certain targeting to immune cells by DC cells; the third generation of CAR-T and TCR-T added to gene editing technology With the birth of ACTL, immunotherapy has gradually moved to a more precise field. Today, with the advent of immunological checkpoints and tumor vaccine technology, tumor immunotherapy begins to focus on how to help patients build longer-term anti-tumor immunity and how to work with surgery, radiotherapy, chemotherapy, etc. Target synergy to achieve a therapeutic effect of 1+1>2. With the deepening of scientists' research on the mechanism of radiotherapy-assisted immunotherapy, more and more cancer clinicians are aware of the significant role of radiotherapy in immunotherapy. Radiotherapy is not only a topical treatment, it has become an important part of systemic therapy. Radiation therapy is currently the most widely used technology in the world with the most treatment sites. As the leader in traditional radiotherapy, proton therapy maximizes the effective utilization of radiation dose, and the side effects of patients are almost no, and the quality of life of patients after treatment is optimal. Radiation beam irradiation of tumor cells From a macroscopic point of view, tumor immunotherapy uses biological means to enhance the killing effect on the tumor by regulating the body's immune recognition and attack ability, especially for small lesions that are not visible in imaging. Immunotherapy has great significance for inhibiting the recurrence and metastasis of tumors. Radiotherapy, as a means of local treatment, has become an important "helper" for immunotherapy. The authoritative magazine "Cell" describes the mechanism of radiotherapy and immunity Cell's Trends in Cancer has published a report entitled "Radiotherapy: Changing the Game in Immunotherapy," which discusses a combination of radiotherapy and immunotherapy strategies. It is pointed out that preclinical data indicate that radiotherapy can make tumors lacking lymphocyte infiltration sensitive to immune antibodies by stimulating anti-tumor T cells, and radiation therapy is a potentiating agent for immunotherapy. Anti-tumor T cell 1. The mechanism of radiotherapy to activate anti-tumor immune response In 2012, two clinical cases reported that after local radiotherapy in melanoma patients, the level of existing tumor-specific antibodies increased, T cell activation index increased, and new anti-tumor specific antibodies appeared. In the local radiotherapy of tumors, the phenomenon of distant metastasis and shrinkage at the same time shows that radiotherapy activates the body's immune response, and radiotherapy combined with immunotherapy is significantly better than the single treatment. 2. Radiotherapy promotes tumor antigen amplification, alteration and expression Due to gene mutations, most antigen expression of malignant tumor cells is different from normal tissue cells, and radiotherapy can promote the expression of tumor-associated antigens and promote the production of new tumor antigens, and activate anti-tumor immune responses. Radiotherapy can lead to cancer cell necrosis, concentrated release of a large number of antigens, and attract immune cells to the tumor site to kill cancer cells. At this time, the combined use of immunotherapy enhances the tumor-specific immune effect by promoting antigen presentation and reducing immunosuppressive factors in the tumor microenvironment. Cell death Radiotherapy and immune combination further enhance the treatment effect A report in Cell indicates that some new trials are providing data support for the joint model of "radiotherapy + immunotherapy". The combination of the two can further enhance the tumor-specific immune effect, and is currently the simplest and most cost-effective method. In the era of immunotherapy, the combined advantages of radiotherapy and immunotherapy as a golden partner will make it an important model for cancer treatment. 1. Further improve the individualization of overall tumor treatment From the point of view of tumor geometry, in vivo location distribution, and radiophysics, each treatment is individualized. Radiotherapy combined with immunotherapy induces a specific anti-tumor immune response against cancer patients, thereby improving the efficacy of personalized treatment. Preclinical and clinical evidence suggests that radiotherapy kills tumor cells and releases the expression of some new tumor antigens that were not previously found in these patients, thereby initiating a new immune response against T cells from tumor cells in patients. T cell immune response 2, radiotherapy combined with immunotherapy to superimpose the advantages of the two Compared with the currently widely used cancer treatment methods, radiotherapy combined with immunotherapy has its unique superiority. Especially for the treatment of solid tumors, high-dose cytotoxic chemotherapy drugs may have a strong killing or inhibiting tumor growth effect on their sensitive tumor cells. Under normal circumstances, a few resistant tumor cells can be obtained. Surviving, leading to future tumor recurrence and metastasis. However, the combination of radiotherapy and immunotherapy maximizes the “hunting†of solid tumors. Radiotherapy is performed on larger tumors, and immune tumors are closely related to microscopic tumors. The combination of the two will maximize the killing of tumor cells. . 3, the effect of patients in the advanced stage is more prominent Radiotherapy is more effective in treating patients in the early and middle stages because of its physical characteristics, but it is more inferior to the effect of patients with advanced and recurrent metastasis. The therapeutic effect of immunotherapy on recurrent metastatic tumors is extremely prominent. When the two are combined, the advanced tumors will suffer from double lethality. With the accumulation of clinical experience, the model of “radiotherapy + immunotherapy†will be further optimized, so that more and more cancer patients will benefit from it. Cooking Wine,Rice Cooking Wine,Onion Ginger Cooking Wine,Sour Cooking Wine Chinese Seasoning (Shandong) Trading Co.,Ltd , https://www.zt-trading.com
