Organ technology on human chips has now reached a level of comfort that reflects the health, electrical activity and differentiation of cells without invasiveness. The emergence of chip organs has made a very big change in scientific research. As a powerful tool, chip organs allow researchers to study the physiological conditions of human tissues and organs in an unprecedented way. By simulating normal blood flow, mechanical microenvironment, and how different tissues interact in living organs. They provide a more systematic approach to testing drugs than other in vitro methods and are ultimately expected to help replace animal testing. In a matter of weeks, human cells grow on the chip into fully differentiated, functional tissues, such as the chip organs that mimic the lungs and intestines, and researchers are looking for ways to understand how drugs, toxins, and other interferences are. Change the structure and function of the organization. The team from the Weiss Institute, led by Don Ingber, is looking for a way to monitor the health and maturity of cells in those microfluidic devices for long periods of non-invasive monitoring. This is very different from measuring the electrical function of cells in the organ of the chip. For example, the brain cells of the brain or the cardiomyocytes of the heart, whether they are in the process of differentiation or responding to drugs, their electrical activities are very active. Now, the Ingber team is working with the team of Kit Parker, a member of the Weiss Core Academy, to work together to find solutions to these problems. The transepithelial electrical resistance (TEER) can be accurately and continuously detected by organ chips with embedded electrodes. TEER is widely used to measure tissue health and differentiation, as well as to assess live cell electrical activity in real time, as in the cardiac chip model. "These electrically active chip organs can help open a window that lets us understand how human cells and tissues function in the organ environment without having to enter the body or remove the cells from the chip," Ingber said. "We are now real-time. Study how different tissue barriers are damaged under infection, radiation, drug exposure, and malnutrition, and when and how they heal in response to reconstruction therapy." Piezoelectric System Scaler,Dental Piezo Scaler,Dental Piezosurgery Scaler,Piezo System Scaler Rolence Enterprise Inc. , https://www.rolencedent.com