Release date: 2015-11-20 Why do some people have a bad sense of direction? This may be related to the genetic variation of the magnetic magnetic resonance protein MagR in the body, and the publication of the "bio-compass" structure will open the wave of "magnetic genetics" research. Animals (butterflies, pigeons, sea turtles, wolves...) migrate by sensing the direction of the magnetic field. Scientists believe that there should be some protein in the animal that can induce geomagnetism, the magnetic receptor protein, but the molecular mechanism behind the protein is unclear. . Until 2008, a journal published in Nature (Nature) revealed that there is a photosensitive cryptochrome protein complex (Cry) in Drosophila. Once knocked out, the sensitivity of Drosophila to direction is reduced. Professor Xie Can pointed out that Cry protein is not a true magnetic induction receptor protein because it cannot sense the polarity of the magnetic field (south, north pole). Source: Bio-Exploration Plant extracts refer to a class of substances derived from plants that have one or more biological functions. Can be separated by physical and chemical extraction of one or more effective components formed by natural products. plant extract,buy plant extract,wholesale plant extract,plant extract benefits,plant extract for sale Shaanxi YXchuang Biotechnology Co., Ltd , https://www.peptidenootropic.com
Why do some people have a bad sense of direction? This may be related to the genetic variation of the magnetic magnetic resonance protein MagR in the body.
On November 16th, the Nature website issued a congratulatory message: the Chinese team of Professor Xie Can's team published a "bio-compass" structure with an identification direction in the animal - consisting of a magnetic induction protein named MagR and a photosensitive cryptochromic protein. Iron-containing complex (MagR/Cry). This heavy discovery and sharing by Prof. Xie Can will open the wave of research on “magnetic genetics†based on the bio-compass structure in the scientific community.
On the same day, the paper "A magnetic protein biocompass" by Professor Xie Can's research team of the Peking University School of Life Sciences was accepted and published online by Nature Materials, a natural material with a factor of 36. The Xiecan research team screened the Drosophila genome to find a protein chelate (CG8198) containing iron and sulfur, which interacted with the Cry protein to form an external body that senses the external magnetic field. Based on the magnetic induction capability of this protein, Xie Can team named CG8198 as magnetic induction receptor protein (MagR).
What is the reason to help the animal indicate the direction? In the past 10 years, scientists have used the light-sensing ability of certain proteins to manipulate neuronal cells, such as inserting a fiber-optic cable directly into the brain to regulate the activity of individual nerve cells, known as optogenetics. learn.
After more than six years of research, Professor Xie Can's team found that magnetic induction receptor proteins have a more dominant advantage than optogenetics, which can be manipulated by magnetic fields outside the brain. Therefore, the team's major discovery will allow scientists to control cells through magnetic fields.
Nature interviews Xie Can - about the "grab the paper"
In April of this year, Zhang Shengjia, a professor at Tsinghua University (now dismissed), obtained the magnetic receptor gene from Xie Can's laboratory, expressed it in the muscles and nerve cells of the nematode, and successfully used the magnetic field to control muscle contraction and nerve activation. Zhang Shengjia, in the absence of knowledge of Xie Can, preemptively delivered articles to Science Bulletin (Science Bulletin, IF 1.579), which has far fewer impact factors than Nature (IF 41.456) and has a quick review experience. The latter's online publication. To this end, this incident caused academic disputes at home and abroad. Tsinghua and Peking University jointly sent a letter to the editorial department of the scientific circular, stating that Zhang Shengjia violated academic norms and required journals to be retracted.
Professor Xie Can said that as early as April of this year, he had applied to the Chinese patent application agency for patents related to magnetic genetics and MagR protein's ability to manipulate macromolecules. They found that the MagR/Cry protein complex is found in many animals including pigeons, butterflies, and whales. He hopes that MagR will have the same function in other animals such as humans.
Why do some people have a bad sense of direction? He speculated that this may be related to the genetic variation of the human magnetic resonance protein MagR.
International academic circles - how do you view Professor Xie Can's research results?
According to Nature News, Peter Hore, a biochemist at the University of Oxford in the United Kingdom, believes that the discovery of the bio-compass structure is a landmark. Unfortunately, there is no analysis of the mechanism of the magnetic receptor protein-induced magnetic field in the article. See the team's further data disclosure.
The neuroscientist David Keays of the Institute of Molecular Pathology in Vienna appears to be cautious. The article may be an extraordinary discovery. If it is not true, it is completely wrong. Because of the scarcity of iron ions in the protein, it has to be made in the cell. The measurability of the magnetic strength is suspect.
For the question of international scientists, Professor Xie Can said that the article only summarizes and publishes the results of the past six years, and hopes that more laboratories will join in to study the depth and breadth of the genes regulating MagR protein.
Bio-Exploration Interview with Professor Xie Can——Exploring the Inspiration Source of His Research on Bio-Compass
To this end, Bio-Exploration also interviewed Professor Xie Can and asked him why he chose the direction of magnetic induction as a research topic. He said: "Time, location, people and" and a lot of contingency factors let him into this field.
First, as a researcher, research interest is the biggest motivation to maintain a monotonous research life. Professor Xie said that his own sense of direction is very poor. Three years after he first entered Peking University, he often lost his way on campus. "Curious" made him want to find this reason. After many efforts, he could not find an answer until 2008. In the year of seeing the article, the article silenced the protein for the first time, confirming its relevance to animal sensing and migration. So inspired, the design and verification of the experiment was carried out. In his view, in 2008, the publication of paper coincided with his curiosity, which constituted the "time of day."
Secondly, multidisciplinary and interdisciplinary expertise is the most valuable "weapon" for a researcher. Professor Xie Can teaches the direction of professional eco-animals in the university. He majored in plant biology and structural biology at the graduate level. He studied PhD at Harvard University. For molecular immunology. At the same time, Peking University issued an invitation letter to overseas students. Professor Xie Can said very modestly that he decided to return to China because he had no resources and ability to independently carry out magnetic induction problems abroad (talking about patriotism is a bit big). Ever since, with the help of the party and the country and Peking University, he quickly established his own laboratory at Peking University and launched a magnetic induction project. In his view, the olive branch handed out by Peking University is the "land advantage" that motivates it to achieve results.
Finally, in foreign countries, “experiment is a game for rich people.†Without sufficient capital, it is impossible to establish laboratories, purchase instruments and equipment, and scientific research work may be interrupted at any time. Professor Xie, who is widely involved in professional education, said that on the one hand, after he joined the company, Peking University allocated a large amount of funds to him, providing food reserves for his dedicated research work; on the other hand, he found the MagR gene in 2012, Sweden. A biotechnology company provided a large molecular screening column for its laboratory, which facilitated the smooth extraction of protein. In his view, "human harmony" is the third element of its emergence in this field.
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