Herpes virus assembly mechanism reveals April 10, 2018 Source: Science and Technology Daily "Science" magazine recently published a research paper on the assembly mechanism of herpes virus, such as the researcher of Rao Zihe and the academician Wang Xiangxi. This work provides a basis for further study of the assembly of viral nucleocapsids and envelope proteins and for the antiviral treatment of herpesviruses. At the same time, it can design herpesviruses as oncolytic viruses based on structure, providing a broad treatment for tumors. Application prospects. It is known that herpesvirus is a large-scale double-stranded DNA virus widely spread around the world, containing a wide variety of viruses and capable of infecting a variety of mammals including humans. According to data from the World Health Organization in January 2017, approximately 4.2 billion people (about 80%) under the age of 50 are infected with herpes simplex virus. Herpes virus is about 200 nm in diameter and contains a four-layer structure of surface capsule, protein intermediate layer, nucleocapsid particle and DNA core. Among them, the diameter of the nucleocapsid is about 125 nm, which plays a very important role in the replication, assembly, maturation and infection of the virus. According to reports, the nucleocapsid contains three types of A, B, and C, and the three types of nucleocapsids are non-standard icosahedrons. The type A nucleocapsid is empty and does not contain other proteins and viral genomes; the type B nucleocapsid contains scaffold proteins; the C-type nucleocapsid contains a viral genome and can mature gradually to become a mature with invasive proliferation activity. virus. In the past 20 years, many scientists in the world have tried to analyze the three-dimensional structure of the herpesvirus nucleocapsid using cryo-electron microscopy. However, due to the large particle size, the ice layer is too thick, the signal-to-noise ratio is reduced, and the Ewald ball effect is Progress in this area is slow. The work of Raozi and the team reported for the first time the 3.1 Ã… atomic resolution structure of the herpes simplex virus nucleocapsid of the herpesvirus alpha family, illustrating the complex interactions and fine structural information of the nucleocapsid protein. The assembly mechanism of the herpesvirus nucleocapsid. This work was commented by industry experts as "the pinnacle of viral structure research, and even broke the limits of traditional cryo-electron microscopy research in a certain sense." (Reporter Xiu Xiuying) China Extract Powder For Use As Dietary Supplement Extract Powder, Extract Powder Manufacturer Shaanxi Kang New Pharmaceutical co., Ltd. , https://www.kangnewpharmas.com