Tripterine can treat cholestatic liver injury March 28, 2019 Source: Science and Technology Daily Researchers at the Kunming Institute of Botany, Chinese Academy of Sciences recently found that tripterygium isolated from the Chinese medicine Tripterygium wilfordii significantly reduced the inflammatory response of the cholestatic liver injury model and restored the dynamic balance of bile acid metabolism, thereby treating cholestatic. liver damage. Tripterine is a triterpenoid chemical component isolated from the Chinese herb Tripterygium wilfordii, which is a bitter and poisonous. Studies have shown that it has anti-inflammatory and anti-cancer effects, and can also inhibit the proliferation, occurrence, development and migration of a variety of tumor cells. In 2007, tripterine was listed by Cell magazine as one of the five most natural products that could be developed into drugs. Recently, there have been reports that tripterine has a good anti-obesity effect. Therefore, its activity and mechanism research have received much attention at home and abroad. The Li Fei research team of the Frontier Interdisciplinary Team of Natural Medicine Chemistry of the Kunming Institute of Botany, Chinese Academy of Sciences has long been concerned with the development of drugs for nuclear receptors and major diseases. Recently, they have found that tripterine can significantly reduce the efficacy of the inflammatory response in the model of cholestatic liver injury. Through metabonomics, it was revealed that tripterine can exert hepatoprotective effects by regulating the corresponding signaling pathways. Subsequently, the research team cooperated with the Second Affiliated Hospital of Kunming Medical University and the First People's Hospital of Yunnan Province to confirm the Tripterygium wilfordii. It can protect against cholestatic liver damage by regulating the corresponding signaling pathway. These findings have been published in the prestigious international journal "Molecular and Cellular Proteomes" with the topic "Talbergrein is resistant to cholestatic liver damage by regulating the sirt1-fxr signaling pathway" and "regulating fat metabolism by tripterine". "School" and "Proteomics Research" magazine. (Reporter Zhao Hanbin) Make-Up Remover,Makeup Remover,Eye Makeup Remover,The Makeup Remover Guangzhou Lingxue Cosmetics Co., Ltd , https://www.lxgj188.com