Killing Plasmodium falciparum in as little as six minutes February 28, 2019 Source: Science and Technology Daily Science and Technology Daily, Beijing, February 27 (Reporter Zhang Mengran) British "Nature" magazine published a new study on infectious diseases online on the 27th: American scientists proposed a strategy to use special anti-malaria in addition to pesticides. Drug treatment to help stop the spread of malaria. This new approach will help control malaria in areas where mosquito populations are resistant, significantly reducing the impact of pesticide resistance on global health. PCR System,Quantitative PCR Machine,Pcr Analyzer,Quantitative PCR System Nanjing Superyears Gene Technology Co., Ltd. , https://www.superyearsglobal.com
Malaria is an insect-borne disease caused by the infection of Plasmodium by the bite of an Anopheles or the blood of a person with Plasmodium. It is currently believed that one of the most effective ways to prevent the spread of malaria is to use mosquito nets sprayed with pesticides. However, Anopheles mosquitoes are becoming increasingly resistant to pesticides, and the risk of malaria transmission is on the rise. Therefore, scientists urgently need to find new ways to control the disease.
This time, the scientist of the Harvard University Chen Zengxi School of Public Health, Flaminia CaterÃa, and his colleagues proved that the female Anopheles gambiae is exposed to parasitic inhibitors, such as attorikone (a type already used in humans). Antimalarial drugs can prevent the development and spread of the malaria parasite Plasmodium falciparum.
Studies have shown that to achieve this effect, only low doses of the drug, plus exposure times as low as 6 minutes, are similar to the time the mosquito stays on the mosquito net while looking for a host. Atormone inhibits the normal functioning of mitochondria in P. falciparum cells, killing parasites and preventing their spread, but does not affect mosquito survival and reproduction.
The report said that other drugs with the same target as attorixone had similar effects, suggesting that parasite mitochondrial function is an excellent target for preventing Plasmodium falciparum in mosquitoes.
The researchers used a simulation to study how the effects they observed affect the dynamics of malaria transmission. According to their simulations, treatment of mosquito nets with Plasmodium falciparum inhibitors can significantly alleviate the impact of pesticide resistance on global health.
The editor-in-chief of Plasmodium falciparum is parasitic on Anopheles mosquitoes. The direct idea is to kill mosquitoes. The malaria parasites have no media and naturally break the transmission path. However, the evolved Anopheles have become more and more powerful, and insecticides have blocked the spread of Plasmodium. Now, scientists use human antimalarial drugs to directly kill the Plasmodium in the Anopheles, and cut off the source of the disease. This way, even if there are more Anopheles mosquitoes, it is just a common worm, not a vector that people talk about and change their hatred.