The United States has designed a single nanoparticle for 8 biomedical applications

Release date: 2014-08-28

A nanoparticle can treat diseases

Designing a single nanoparticle for 8 biomedical applications

In the future of disease diagnosis and treatment, a nanoparticle is enough? Published in a nanotechnology paper on August 26th in the British journal Nature, published a flexible nanoparticle design for eight different biomedical applications, the first to offer such a wide range of clinically relevant functions. A single preparation that is "in one set." This research in mice has the potential to further advance the development of personalized nanomedicine and the treatment of specific patients.

Nanoparticles generally refer to an artificially manufactured microparticle that does not exceed 100 nanometers in size. It can bridge the gap between large materials and atoms and molecules. It is a promising tool for disease diagnosis and treatment, and gradually enters the clinical field. But so far, in every application, the nanoparticles are usually adjusted and optimized, which limits the use of a single nanoparticle structure.

This time, Kitt Lyme and colleagues at the University of California, Davis Cancer Center reported a simple nanoparticle design based on a single chemical building block called nanoporphyrin. This nanoparticle is very flexible and can be used in 8 different biomedical applications. Although these biological applications cannot be performed simultaneously, they still have extraordinary medical value.

Among these applications are imaging technologies such as near-infrared fluorescence imaging, magnetic resonance imaging (MRI), positron emission computed tomography (PET), and dual-mode positron emission tomography (PET-MRI) systems. Etc. Nanoporphyrin can also be further used in photothermal and photodynamic therapy, using light to heat nanoparticles; or generating oxygen free radicals to target the destruction of malignant cells; at the same time, nanoporphyrins can also be targeted to deliver drugs.

The authors point out that this is the first report that an organic nanoparticle system can integrate such a wide range of clinically relevant functions into a single formulation. It is expected to promote the application of nanotechnology in the medical field, and promote the realization of accurate diagnosis, reliable treatment and become a new weapon for disease prevention.

However, the researchers also said that at present, whether the system is also applicable to humans, further research is needed.

Source: Technology Daily

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