Can we cure the wound by printing the skin?

Researchers have recently developed a bio-skin printing system that prints cortical layers to help treat chronic wounds or burns.
Scientists at the Wake Forest Regenerative Medicine Institute (WFIRM) in Winston-Salem, North Carolina, invented a bioprinting technology that uses the skin cells of the body as a material and prints it directly on the wound. . The findings were published in the journal Scientific Reports.
First, skin cells, including dermal fibroblasts and epidermal keratinocytes, are obtained from a person's normal skin tissue. The cells are then expanded in vitro and mixed with the hydrogel. Put it into a bioprinter that scans the patient's wound, enters the data into the computer, and controls the printing device to print.
The resulting skin is unique and can match a person's actual wound shape, depth, etc. without the need for donor skin grafting. This technology restores the skin's natural function and accelerates the natural formation of the skin, which means that the wound heals faster and with less risk.
"The unique feature of this technology is the mobility of the printing system, as well as the individualized precision treatment by scanning and measuring large areas of wounds," said Dr. Sean Murphy, lead author of the study.
It is difficult to heal a wound in a chronic wound. It usually takes 4-6 weeks to heal, depending on the severity and size of the wound. However, if it does not heal during this time, a chronic wound is formed. Many factors can lead to the formation of chronic wounds such as diabetes and malnutrition.
There are many ways in which health care workers can heal chronic wounds. The use of wound dressings is an important method, but its price and effect vary. For large areas of chronic wounds and burns, skin grafting is another option. Skin grafts can come from another part of the body, called autologous transplantation, or can be transplanted with skin substitutes.
Bio-skin printing can revolutionize wound healing. Dr. James Yoo, who led the research team, explained that bio-skin printing can make wounds begin the healing process faster.
He also mentioned that other treatments do not really create skin like this method.
Researchers point out that skin grafts are common, but they also have a number of shortcomings. For example, autotransplantation is difficult to implement due to the lack of healthy tissue. In addition, allogeneic skin grafts are at risk of tissue rejection. New bioprinting technology helps to improve these risks because it allows the skin to grow outward from the center of the wound, an advantage that only exists in autologous transplants.
Although the researchers have demonstrated how this approach works on the model, the next step is to conduct human clinical trials. It is unclear when this technology will enter the clinic and become the standard for wound treatment. However, this is a beginning of hope.

Source: Omelette

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