Hematopoietic stem cells are "primary progenitor cells" in the blood system, which sustain life by multiplying cells such as leukocytes by proliferation and differentiation. Hematopoietic stem cells need to be successfully homing to hematopoietic tissue before they can function, and understanding the whole process of homing is the key to improving the success of clinical stem cell transplantation. Recently, Chinese scientists have directly observed the complete process of hematopoietic stem cell homing for the first time in the world, and there are many original discoveries. The research was published on the internationally renowned academic journal Nature on the 20th. The team led by Pan Weijun, a researcher from the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, led the team for 6 years, integrating live immunofluorescence labeling, genetic regulation and graph reconstruction calculations. Time-course in vivo imaging statistical analysis found that the hotspots of hematopoietic stem cells homing, the special venous microvascular structures in the homing microenvironment, and the novel cells that can recognize and direct the hematopoietic stem cells to homing - "leading cells." “The real process of hematopoietic stem cell homing is very interesting. It carries a protein that is positioned to find the most suitable 'home' in the hematopoietic tissue, which is the hot spot for homing. The 'doorway' of the hotspot will be 'Pilot cells' patrol, after successful identification, hematopoietic stem cells will proliferate and differentiate in 'home'." Pan Yujun said. Chen Wei, director of the Department of Hematology at Huashan Hospital affiliated to Fudan University, believes that the research results fundamentally analyze the state of hematopoietic stem cells and bone marrow microenvironment, and have important application prospects in hematopoietic stem cell transplantation and prevention of distant metastasis of tumors. Jing Naihe, a researcher at the Biochemical Cell Institute of the Chinese Academy of Sciences, said that bone marrow transplantation usually takes tens of millions of cells from the donor, of which there are millions of hematopoietic stem cells, and fewer hematopoietic stem cells that actually homage are more objective. It caused a certain amount of cell waste. This study helps us to understand the specific mechanisms of the interaction between hematopoietic stem cells and the hematopoietic microenvironment. In the future, bone marrow transplantation will no longer require the extraction of so many cells, which can greatly improve the efficiency of transplantation. Spreader, L Shape Spreader, L-shape Spreader, Lab Bacterial Culture Spreder, Plastic Spreader Spreader,L Shape Spreader,L-shape Spreader,Lab Bacterial Culture Spreder,Plastic Spreader Luck Medical Consumables Co.,LIMITED , https://www.luckmedical.com