Scientists have found that chiral molecular splitting tools are expected to reduce the cost of chiral drug production November 20, 2018 Source: Health News Author: Li Zhe The National Key Laboratory of Medicinal Chemistry Biology, School of Pharmacy, Nankai University, Chen Yao, Research Fellow, Professor Zhang Zhenjie from the School of Chemistry, and Prof. Ma Shengqian from the University of South Florida, used the biomolecular induction strategy to design and synthesize a kind of chiral covalent Organic framework materials have been successfully applied to the chiral separation of small molecules such as drugs and amino acids. The material has the characteristics of low cost, high efficiency and universality. It has completely independent intellectual property rights. As a new "breakup" weapon, it will greatly reduce the production cost of chiral drugs and break the dependence on imports. The paper introducing the work was published online in the internationally renowned academic journal "German Applied Chemistry". In the late 1950s, a drug “response stop†(thalidomide), which slowed the pregnancy response in women, led to the birth of more than 10,000 congenital malformations (sea seal limbs) in the world. Later, scientists found that there are chiral molecules in the "reaction stop", in which the right-handed molecule has a central sedative effect, while the left-handed molecule has teratogenic side effects. This is the result of insufficient cognition of "chiral molecules." In the chemical world, there are a large class of molecules with chiral isomers, called "chiral molecules." The two mirror-isomers of chiral molecules in some drugs have significant differences in biological activity, metabolic processes, and toxicity, and some are the difference between "treatment" and "pathogenicity." How to separate the "left and right hands" of chiral molecules economically, efficiently and conveniently, and obtain the beneficial parts, has become a topic of competition in the chemical industry. At present, liquid chromatography is one of the important means to obtain a single configuration enantiomer of chiral molecules, and a chiral stationary phase with high chiral separation performance is the key to this technology. “In short, the separation column in the liquid chromatograph is like a tunnel. The car with the same appearance and model looks exactly the same. If the car is in the license, the traffic police can make it pass smoothly. If there is no license, It will be passed behind because of the traffic police investigation. In this way, the other end of the tunnel will be the licensed car, and the car will appear after the unlicensed car." Chen Yao said that the most critical part of this is "traffic police." ", that is, "chiral stationary phase", requires strong recognition, stability and efficiency. Biomolecules (such as enzymes, peptides, amino acids, etc.) can be used for the identification of various chiral molecules due to their inherent chiral structure and their amphiphilic and zwitterionic properties, but the stability is poor. The emerging porous framework materials, covalent organic framework materials (COFs), have high specific surface area, high channel ratio, easy pore size control, flexible structure, easy functionalization, and excellent thermal stability and chemistry. stability. After a series of technical research, Chen Yao's research group successfully introduced a series of biomolecules (lysozyme, tripeptide, amino acid) into COFs materials. The achiral COFs become chiral COFs by inheriting the chiral characteristics of biomolecules. Further, it can be applied to the resolution of chiral molecules. “This is equivalent to having an efficient and dedicated 'traffic policeman' in the tunnel – a new type of high performance liquid chromatography chiral stationary phase has been synthesized by us.†Chen Yao said. “This research offers great potential for the development of efficient, durable chiral stationary phases and the broadening of covalent organic framework materials for chiral separation and chiral catalysis applications.†Medical Swabs,Gauze Swab Online,Disposable Gauze Swab,X-Ray Detective Gauze Swab Xinxiang Huaxi Sanitary Materials Co., Ltd. , https://www.huaximedical.com